Size-optimized simvastatin TPGS modified lipid nanocapsules for targeting epithelial-to-mesenchymal transition in hepatocellular carcinoma: role of PTEN/AKT signaling.
Khaled MahmoudMahmoud TeaimaYasmeen AttiaMohamed El-NabarawiShady A SwidanPublished in: Expert opinion on drug delivery (2023)
The present study, therefore, suggests the efficacy of the 50 nm particles in SIM-loaded LNC in HCC by targeting EMT via modulating the PTEN/AKT signaling axis.