Synthesis of Z-Enamides through Heterogeneous Gold-Catalyzed Stereoselective Hydrogenation of Ynamides.

A facile synthesis of Z-enamides via heterogeneous Au/TiO2 catalyzed stereoselective hydrogenation of ynamides has been developed. Easy to handle and inexpensive ammonium formate was used as the hydrogen source, and Z-enamides were formed in a highly stereoselective manner. The commercially available gold nanoparticle catalyst could be recycled multiple times without a significant loss of activity.