Aberrant methylation of tumour suppressor genes WT1, GATA5 and PAX5 in hepatocellular carcinoma.

Martin MžikMarcela ChmelařováStanislav JohnJan LacoOndřej SlabýIgor KissLucia BohovicováVladimír PaličkaJana Nekvindová

Published in: Clinical chemistry and laboratory medicine (2017)

HCC evince aberrant promoter methylation of WT1, PAX5, PAX6, PYCARD and GATA5 genes. Correlation between GATA5, WT1 and PAX5 methylation and clinical/histological parameters is suggestive of applicability of these markers in non-invasive (epi)genetic testing in HCC.

Keyphrases

genome wide
transcription factor
dna methylation
genome wide identification
gene expression