Clearance Profile of Circulating Tumor Human Papillomavirus DNA During Radiotherapy Predicts Clinical Outcomes in Human Papillomavirus-Related Oropharyngeal Cancer.

Hidenori Tanaka Atsuhiko Uno Yukinori TakenakaMotoyuki SuzukiYuji Seo Norihiko TakemotoTakahito FukusumiHirotaka EguchiHaruka KanaiMasafumi HorieFumiaki IsohashiKazuhiko OgawaHirotsugu Shiroma Hidenori Inohara

Published in: JCO precision oncology (2023)

In patients with HPV16-related oropharyngeal squamous cell carcinoma receiving radiotherapy, a slow ctHPV16DNA clearance profile could prelude unfavorable outcomes. Monitoring ctHPV16DNA is essential for determining the clearance profile, which might help optimize treatment intensity individually.

Keyphrases

circulating tumor
cell free
circulating tumor cells
squamous cell carcinoma
locally advanced
early stage
radiation therapy
papillary thyroid
single molecule
high grade
metabolic syndrome
high intensity
type diabetes
insulin resistance
drug induced
cervical cancer screening