Dysregulated glucuronic acid metabolism exacerbates hepatocellular carcinoma progression and metastasis through the TGFβ signalling pathway.

Qingzhu GaoBin ChengChang ChenChong LeiXue LinDan NieJingjing LiLuyi HuangXiaosong LiKai WangAilong HuangNi Tang

Published in: Clinical and translational medicine (2022)

GSTZ1 deficiency and subsequent up-regulation of the glucuronic acid metabolic pathway promotes HCC metastasis by increasing the stability of TGFβR1 mRNA and activating TGFβ/Smad signalling. UGDH and a key metabolite, UDP-GlcUA, may serve as prognostic markers. Targeting UGDH might be a promising strategy for HCC therapy.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
signaling pathway
cancer therapy
bone marrow
binding protein
smoking cessation