Gene Expression Profile of High IFN-γ Producers Stimulated with Leishmania braziliensis Identifies Genes Associated with Cutaneous Leishmaniasis.

Marcia W CarneiroKiyoshi F FukutaniBruno B AndradeRebecca P CurveloJuqueline R CristalAugusto M CarvalhoAldina BarralJohan Van WeyenberghManoel Barral-NettoCamila I de Oliveira

Published in: PLoS neglected tropical diseases (2016)

Upon interrogation of the peripheral response of naive individuals with diverging IFN-γ production to L. braziliensis, we identified differences in the innate response to the parasite that are recapitulated in vivo and that discriminate CL patients from individuals presenting a subclinical infection.

Keyphrases

immune response
gene expression
end stage renal disease
ejection fraction
newly diagnosed
dendritic cells
chronic kidney disease
dna methylation
prognostic factors
genome wide
patient reported outcomes