NNRTI-induced HIV-1 protease-mediated cytotoxicity induces rapid death of CD4 T cells during productive infection and latency reversal.
Benjamin TrinitéHongtao ZhangDavid N LevyPublished in: Retrovirology (2019)
This work supports the notion that select NNRTIs might help promote the elimination of HIV-1 producing cells as an adjuvant during shock and kill therapy.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- induced apoptosis
- men who have sex with men
- early stage
- cell cycle arrest
- high glucose
- south africa
- diabetic rats
- endoplasmic reticulum stress
- signaling pathway
- quantum dots
- loop mediated isothermal amplification
- pi k akt
- sensitive detection