Joint-label fusion brain atlases for dementia research in Down syndrome.
Nazek QuederMichael J PhelanLisa TaylorNicholas TustisonEric DoranChristy HomDana NguyenFlorence LaiMargaret PulsiferJulie PriceWilliam C KreislHerminia D RosasSharon Krinsky-McHaleAdam M BrickmanMichael A YassaNicole SchupfWayne SilvermanIra T LottElizabeth HeadMark MapstoneDavid B Keatornull nullPublished in: Alzheimer's & dementia (Amsterdam, Netherlands) (2022)
Down syndrome (DS) joint-label-fusion atlases provide accurate positron emission tomography (PET) amyloid measurements.A disorder-specific DS atlas is better than a neurotypical atlas for PET quantification.It is not necessary to use a disease-state-specific atlas for quantification in aged DS.Dorsal striatum results vary, possibly due to this region and dementia progression.