CPNE1 promotes non-small cell lung cancer progression by interacting with RACK1 via the MET signaling pathway.

Anqi WangWen YangYue LiYang ZhangJieqi ZhouRuochen ZhangWeijie ZhangJianjie ZhuYuanyuan ZengZeyi LiuJian-An Huang

Published in: Cell communication and signaling : CCS (2022)

Our findings show that CPNE1 promotes tumorigenesis by interacting with RACK1 and activating MET signaling. The combination of a MET inhibitor with an EGFR-TKI attenuated tumour growth more significantly than either single-drug treatment. These findings may provide new insights into the biological function of CPNE1 and the development of novel therapeutic strategies for NSCLC. Video Abstract.

Keyphrases

induced apoptosis
signaling pathway
tyrosine kinase
epidermal growth factor receptor
small cell lung cancer
pi k akt
oxidative stress
advanced non small cell lung cancer
epithelial mesenchymal transition
protein kinase
emergency department
cell proliferation