Facile synthesis of O -acylhydroxamates via reaction of oxime chlorides with carboxylic acids.

A simple and efficient method for the synthesis of O -acylhydroxamate derivatives from oxime chlorides and carboxylic acids was developed. The reaction affords clean and facile access to diverse O -acylhydroxamates in high yields (up to 85%). The chemical structure of a typical product was confirmed using single-crystal X-ray structure analysis.