Increased cerebral mitochondrial dysfunction and reactive oxygen species with cardiopulmonary bypass.
Lindsay E VolkConstantine D MavroudisTiffany S KoThomas HallowellNile DelsoAnna L RobertsJonathan StarrWilliam LandisYuxi LinMarco HeftiRyan W MorganRichard W MelchiorTami M RosenthalAlexander ChappellDouglas FisherMolly DreherDaniel J LichtJonathan ChenJ William GaynorChristopher E MascioTodd J KilbaughPublished in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021)
Even in the absence of local markers of ischaemia, CPB is associated with decreased mitochondrial respiration relative to shams irrespective of duration. Exposure to 4 h of CPB resulted in a significant increase in cerebral mitochondrial ROS formation compared to shorter durations. Further study is needed to improve the understanding of cerebral mitochondrial health and its effects on the pathophysiology of neurological injury following exposure to CPB.