Bulk T-Cell Receptor Sequencing Confirms Clonality in Pediatric EoE and Identifies a Food-Specific Repertoire.

Rethavathi JanarthanamFei Li KuangAngelika ZalewskiKatie AmsdenMing-Yu WangLorena OstillaKaitlyn KeeleyIkuo HiranoAmir KagalwallaBarry K WershilNirmala GonsalvesJoshua B Wechsler

Published in: Allergy (2023)

We confirmed relative clonality in children but not adults with active EoE and identified potential food-specific TCRs, particularly for milk-triggered EoE. Further studies are needed to better identify the broad TCR repertoire relevant to food triggers.

Keyphrases

human health
young adults
risk assessment
regulatory t cells
gene expression
genome wide
dna methylation
case control