MiR-144-5p, an exosomal miRNA from bone marrow-derived macrophage in type 2 diabetes, impairs bone fracture healing via targeting Smad1.

Dong ZhangYifan WuZonghuan LiHairen ChenSiyuan HuangChao JianAixi Yu

Published in: Journal of nanobiotechnology (2021)

The results demonstrated an important role of exosomal miR-144-5p in bone regeneration, offering insight into developing new strategy for the improvement of fracture healing in patients with diabetes mellitus.

Keyphrases

bone regeneration
type diabetes
glycemic control
hip fracture
epithelial mesenchymal transition
adipose tissue
mesenchymal stem cells
cardiovascular disease
cancer therapy
bone mineral density
metabolic syndrome
signaling pathway