The effects of palbociclib in combination with radiation in preclinical models of aggressive meningioma.

Craig HorbinskiGuifa XiYufen WangRintaro HashizumeMahesh GopalakrishnanJoanna J PhillipsPeter HoughtonCharles D JamesJohn A Kalapurakal

Published in: Neuro-oncology advances (2021)

These data suggest that palbociclib could be repurposed to treat patients with p16-deficient, Rb-intact meningiomas, and that a clinical trial in combination with radiation therapy merits consideration.

Keyphrases

radiation therapy
clinical trial
metastatic breast cancer
radiation induced
electronic health record
big data
stem cells
open label
study protocol
double blind
squamous cell carcinoma
locally advanced
artificial intelligence
optic nerve
phase iii
deep learning