Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways.
Geoffrey CanetEmma ZubCharleine ZussyCélia HernandezMarine BlaquiereValentin GarciaMathieu VitalisFrederic deBockMaria Moreno-MontanoEtienne AudinatCatherine DesrumauxEmmanuel PlanelLaurent GivaloisNicola MarchiPublished in: Epilepsia (2022)
MTLE and a generalized SE prompt persistent and varying tau hyperphosphorylation or amyloidogenic modifications in the hippocampus. In MTLE, an AD-relevant molecular trajectory intertwines with neuroinflammation, spatiotemporally involving epileptogenic and nonlesional seizure propagating zones.