Enantioselective and Regiodivergent Gold and Chiral Brønsted Acid Catalyzed Cycloisomerization/Diels-Alder Reaction of 1,10-Dien-4-yn-3-yl Acetates: Synthesis of Norbornene-Embedded Tricarbocycles.
Andrés Felipe León RojasYing Yan ChongSara Helen KyneBo XiaPhilip Wai Hong ChanPublished in: Organic letters (2024)
A synthetic method for the enantioselective and regiodivergent synthesis of hexahydro-2 H -2,4a-methanonaphthalen-4-yl and octahydro-2,4-methanoazulen-1-yl esters that relies on the gold(I)- and chiral Brønsted acid-catalyzed cycloisomerization/Diels-Alder (CDA) reaction of ( E )-1,10-dien-4-yn-3-yl acetates is described.