Longitudinal Monitoring of Circulating Tumor DNA to Assess the Efficacy of Immune Checkpoint Inhibitors in Patients With Advanced Genitourinary Malignancies.
Albert JangSree M LankaEllen B JaegerAlexandra LiebermanMinqi HuangA Oliver SartorPrateek MendirattaJason R BrownJorge A GarciaTiffany FarmerSumedha SudhamanTamara MahmoodNatalia PajakMark CalhounPunashi DuttaAdam ElNaggarMinetta C LiuPedro C BarataPublished in: JCO precision oncology (2023)
In this pilot study, longitudinal ctDNA analysis for monitoring response to ICI in patients with advanced GU tumors was feasible. Larger prospective studies are warranted to validate the utility of ctDNA as an ICI response monitoring tool in patients with advanced GU malignancies.