An in vitro model for postoperative cranial nerve dysfunction and a proposed method of rehabilitation with N-acetylcysteine microparticles.

Ashley E KitaKatherine KedeshianMichelle HongLarry Hoffman

Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2024)

We developed a Schwann cell culture model of iatrogenic nerve injury and used this to identify N-acetylcysteine as an agent to promote recovery. N-acetylcysteine was packaged into microparticles and demonstrated promise as a locally administrable agent to reduce oxidative stress in Schwann cells.

Keyphrases

peripheral nerve
oxidative stress
induced apoptosis
cell cycle arrest
patients undergoing
dna damage
signaling pathway
ischemia reperfusion injury
cell death
diabetic rats
machine learning
cell proliferation
pi k akt
heat shock