Does the definition of chronic active T cell-mediated rejection need revisiting?

Maarten NaesensMark HaasAlexandre Loupy Candice A Roufosse Michael Mengel

Published in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2020)

Similar to what is observed in native kidneys, tubulo-interstitial inflammation in scarred areas (i-IFTA) is commonly found in kidney allografts, and here independently associated with impaired outcome. Along with the observation that i-IFTA is preceded by acute T cell mediated rejection (TCMR) and/or suboptimal immunosuppression in a subset of cases, these data formed the basis for the introduction of the category of tubulointerstitial (grade I) chronic active TCMR (CA-TCMR) in the 2017 Banff classification.

Keyphrases

drug induced
oxidative stress
liver failure
deep learning
respiratory failure
big data
intensive care unit
artificial intelligence
mechanical ventilation