1-(Benzo[b]thiophen-4-yl)piperazine Ring Induced Bioactivation of Brexpiprazole in Liver Microsomes: Identification and Characterization of Reactive Conjugates Using Ultra-High-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry.
Disha ThakkarAbhijeet S KatePublished in: European journal of drug metabolism and pharmacokinetics (2021)
Brexpirazole is bioactivated due to the presence of a 1-(benzo[b]thiophen-4-yl)piperazine ring in its structure. In contrast to aripiprazole, the quinolinone motif was found latent towards bioactivation in brexpiprazole.
Keyphrases
- tandem mass spectrometry
- ultra high performance liquid chromatography
- major depressive disorder
- liquid chromatography
- high performance liquid chromatography
- simultaneous determination
- gas chromatography
- high resolution mass spectrometry
- mass spectrometry
- solid phase extraction
- high glucose
- high resolution
- diabetic rats
- magnetic resonance
- bipolar disorder
- drug induced
- oxidative stress
- ms ms
- endothelial cells
- computed tomography