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The diversity and clinical implications of genetic variants influencing clopidogrel bioactivation and response in the Emirati population.

Lubna Q KhasawnehHabiba AlsafarHiba AlblooshiMushal AllamGeorge P PatrinosBassam R Ali
Published in: Human genomics (2024)
Recognizing these alleles and genotype frequencies may explain the clinical differences in medication response across different ethnicities and predict adverse events. Our findings underscore the need to consider genetic variations in prescribing clopidogrel, with potential implications for implementing personalized anti-platelet therapy among Emiratis based on their genetic profiles.
Keyphrases
  • acute coronary syndrome
  • percutaneous coronary intervention
  • genome wide
  • antiplatelet therapy
  • primary care
  • adverse drug
  • quality improvement
  • gene expression
  • emergency department
  • dna methylation
  • climate change