Allogeneic haematopoietic stem cell transplantation resets T- and B-cell compartments in sickle cell disease patients.

Luciana Ribeiro JarduliJúlia Teixeira Cottas de AzevedoEmmanuel ClaveThalita Cristina de Mello CostaLucas Coelho Marlière ArrudaIsabelle FournierPatrícia Vianna Bonini PalmaKeli Cristina LimaJuliana Bernardes EliasAna Beatriz Pl StracieriFabiano PieroniRenato CunhaLuiz Guilherme Darrigo-JúniorCarlos Eduardo Settani GreccoDimas Tadeu CovasAna Cristina Silva-PintoGil Cunha De SantisBelinda Pinto SimõesMaria Carolina OliveiraAntoine ToubertKelen Cristina Ribeiro Malmegrim

Published in: Clinical & translational immunology (2022)

Our findings revealed that the T- and B-cell compartments were normally reconstituted in SCD patients after allo-HSCT. In addition, the increase of IL-10-producing B-regulatory cells may contribute to improve immune regulation and homeostasis after transplantation.

Keyphrases

stem cell transplantation
end stage renal disease
ejection fraction
sickle cell disease
newly diagnosed
chronic kidney disease
high dose
prognostic factors
induced apoptosis
cell proliferation
endoplasmic reticulum stress
patient reported