The crucial role of Erk2 in demyelinating inflammation in the central nervous system.

Rentaro OkazakiToru DoiKentaro HayakawaKazuhito MoriokaOsamu ImamuraKunio TakishimaMakoto HamanoueYasuhiro SawadaMotoshi NagaoSakae TanakaToru Ogata

Published in: Journal of neuroinflammation (2016)

Our results suggest that Erk2 activation in astrocytes plays a crucial role in aggravating demyelinating inflammation by inducing inflammatory mediators and gliosis. Thus, therapies targeting Erk2 function in glial cells may be a promising approach to the treatment of distinct demyelinating diseases.

Keyphrases

signaling pathway
oxidative stress
induced apoptosis
pi k akt
cell proliferation
cell cycle arrest
cerebrospinal fluid
spinal cord injury
combination therapy