Pharmacological inhibition of Hippo pathway, with the novel kinase inhibitor XMU-MP-1, protects the heart against adverse effects during pressure overload.
Efta TriastutiArdiansah Bayu NugrohoMin ZiSukhpal PreharYulia Suciati KoharThuy Anh BuiNicholas StaffordElizabeth J CartwrightSabu AbrahamDelvac OceandyPublished in: British journal of pharmacology (2019)
The Hippo pathway inhibitor, XMU-MP-1, reduced cellular hypertrophy and improved survival in cultured cardiomyocytes and, in vivo, preserved cardiac function following pressure overload.