Optimization of dosing regimens of isoniazid and rifampicin in children with tuberculosis in India.
Blessed Winston AruldhasRichard M HoglundJaya RanjalkarJoel TarningSumith K MathewValsan Philip VergheseAnuradha BoseBinu Susan MathewPublished in: British journal of clinical pharmacology (2019)
The exposure to isoniazid is adequate with present regimens. For rifampicin, a novel dosing regimen was developed to ensure adequate drug concentrations in children. However, further studies are required to assess the dose-effect relationship of higher doses of rifampicin.