Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium.
Anagha Inguva ShethKrysta EngelHunter TolisonMark J AlthoffMaria L AmayaAnna KrugTracy YoungShanshan PeiSweta B PatelMohammad MinhajuddinAmanda WintersRegan MillerIan SheltonJonathan St-GermainTianyi LingCourtney JonesBrian RaughtAustin E GillenMonica RansomSarah StaggsClayton A SmithDaniel A PollyeaBrett M StevensCraig T JordanPublished in: bioRxiv : the preprint server for biology (2023)
We identify increased utilization of mitochondrial calcium as distinct metabolic requirement of venetoclax-resistant LSCs and demonstrate the potential of targeting mitochondrial calcium uptake as a therapeutic strategy.