Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation.

Joohyun KimMichael T ZimmermannAngela J MathisonGwen LomberkRaul UrrutiaJohnny C Hong

Published in: Annals of surgery open : perspectives of surgical history, education, and clinical approaches (2024)

We report transcriptomic profiles of human liver allograft IRI from prepreservation in the donor to posttransplantation in the recipient. Immunomodulatory and metabolic landscapes across ER and LR phases were different between IAF and EAD allografts. Our study also highlights marker genes for these biological processes that we plan to explore as novel therapeutic targets or surrogate markers for severe allograft injury in clinical OLT.

Keyphrases

innate immune
kidney transplantation
endothelial cells
single cell
transcription factor
genome wide
early onset
induced pluripotent stem cells
estrogen receptor
breast cancer cells
insulin resistance
weight loss
heat stress
genome wide analysis