Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species.

Juntao FangQiangbing YangRenée G C MaasMichele BuonoBram MeijlinkDyonne Lotgerink BruinenbergErnest Diez BenaventeMichal MokryAlain van MilLi QianMarie-José GoumansRaymond SchiffelersZhiyong LeiJoost P G Sluijter

Published in: Stem cell research & therapy (2024)

Our findings demonstrate that VitC supplementation significantly enhances the efficiency of cardiac reprogramming, partially by suppressing ROS production in the presence of GMT.

Keyphrases

reactive oxygen species
left ventricular
cell death
signaling pathway
dna damage
heart failure