Metabolomic Identification of Predictive and Early Biomarkers of Cisplatin-induced Acute Kidney Injury in Adult Head and Neck Cancer Patients.

Yong Jin LimSteven G XiuM Sara KuruvillaEric WinquistStephen WelchMorgan BlackLauren N FaughtJasmine LeeMichael J RiederTom D Blydt-HansenMichael ZappitelliBradley L Urquhart

Published in: British journal of clinical pharmacology (2023)

We propose glycine, hippuric acid sulfate, 3-hydroxydecanedioc acid, and suberate as predictive biomarkers of predisposition to cisplatin-induced AKI. Metabolites indicative of mitochondrial dysfunction may serve as early markers of subclinical AKI.

Keyphrases

acute kidney injury
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
ms ms
peritoneal dialysis
patient reported outcomes