Immunohistochemical characteristics of local sites that trigger atrial arrhythmias in response to high-frequency stimulation.
Min-Young KimJames NesbittSimos KoutsoftidisJoseph BrookDavid S PitcherChris D CantwellBalvinder HandaCatherine JenkinsCharles HoustonStephen M RotheryAnand JothidasanJustin PerkinsPoppy BristowNicholas W F LintonEmmanuel M DrakakisNicholas S PetersRasheda A ChowdhuryPrapa KanagaratnamFu Siong NgPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2022)
ET sites identified by HFS contained a higher density of smaller nerves than non-ET sites. The majority of these nerves were within the atrial myocardium. This has important clinical implications for devising an effective therapeutic strategy for targeting autonomic triggers of AF.