Disruption of the mouse Bmal1 locus promotes heterotopic ossification with aging via TGF-beta/BMP signaling.

Qian LiangYingsi LuLu YuQingqing ZhuWenlin XieYun WangLiping YeQiji LiShaoyu LiuYan LiuChengming Zhu

Published in: Journal of bone and mineral metabolism (2021)

These findings demonstrated that Bmal1 negatively regulates endochondral ossification in heterotopic ossification of tendons and ligaments with aging via TGFβ/BMP signaling, thereby identifying a new regulatory mechanism in age-related heterotopic ossification of tendons and ligaments.

Keyphrases

mesenchymal stem cells
transforming growth factor
transcription factor
bone regeneration
epithelial mesenchymal transition
bone marrow