Biomarkers for Overweight in Adult-Onset Asthma.

Hiroki TashiroKoichiro TakahashiHironori SadamatsuYuki KuriharaTetsuro HaraguchiRyo TajiriAyako TakamoriShinya KimuraNaoko Sueoka-Aragane

Published in: Journal of asthma and allergy (2020)

The present study showed that overweight patients with adult-onset asthma were characterized by a higher rate of annual exacerbations and worse lung function despite treatment with high-dose inhaled corticosteroids and lower blood eosinophil counts than non-overweight patients with asthma. On blood cytokine and chemokine analyses, a low level of TGF-α and high levels of hsIL-6, RANTES/CCL5, and VEGF-A might be biomarkers reflecting the pathophysiology in overweight patients with asthma.

Keyphrases

lung function
chronic obstructive pulmonary disease
cystic fibrosis
weight loss
air pollution
weight gain
high dose
physical activity
low dose
transforming growth factor
body mass index
drug induced