Focal to bilateral tonic-clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy.
Nishant SinhaNatalie PeternellGabrielle M SchroederJane de TisiSjoerd B VosGavin P WinstonJohn S DuncanYujiang WangPeter Neal TaylorPublished in: Epilepsia (2021)
The whole-brain structural network is altered to a greater and more widespread extent in patients with TLE and FBTCS. We suggest that these abnormal networks may serve as an underlying structural basis or consequence of the greater seizure spread observed in FBTCS.