DNA damage repair pathway alterations in metastatic clear cell renal cell carcinoma and implications on systemic therapy.

Yasser GedJoshua L ChaimRenzo G DiNataleAndrea KnezevicRitesh R KotechaMaria I CarloChung-Han LeeAshley FosterDarren R FeldmanMin Yuen TeoGopakumar IyerTimothy ChanSujata PatilRobert J MotzerA Ari HakimiMartin H Voss

Published in: Journal for immunotherapy of cancer (2021)

Del DDR alterations are recurrent genomic events in patients with advanced RCC and were mostly clonal in this cohort. Loss-of-function events in these genes may affect outcome with I/O therapy in metastatic RCC, and these hypothesis-generating results deserve further study.

Keyphrases

dna damage
squamous cell carcinoma
small cell lung cancer
stem cells
dna repair
copy number
dna methylation
bioinformatics analysis
drug induced