Urine 5MedC, a Marker of DNA Methylation, in the Progression of Chronic Kidney Disease.

Akifumi OnishiHitoshi SugiyamaMasashi KitagawaToshio YamanariKeiko TanakaAyu Ogawa-AkiyamaYuzuki KanoKoki MiseKatsuyuki TanabeHiroshi MorinagaMasaru KinomuraHaruhito Adam Uchida Jun Wada

Published in: Disease markers (2019)

The present data demonstrate that the urine 5MedC level is associated with a reduced renal function and can serve as a novel and potent biomarker for predicting the renal outcome in CKD patients. Further studies will be necessary to elucidate the role of urine DNA methylation in the progression of CKD.

Keyphrases

chronic kidney disease
end stage renal disease
dna methylation
peritoneal dialysis
genome wide
gene expression
machine learning
big data
patient reported outcomes
copy number
case control