Humoral and Cellular Immune Responses to SARS-CoV-2 Infection and Vaccination in Autoimmune Disease Patients With B Cell Depletion.

David SimonKoray TascilarKatja SchmidtBernhard MangerLeonie WeckwerthMaria V SokolovaLaura BucciFilippo FagniKarin MangerFlorian SchuchMonika RonnebergerAxel HueberUlrike SteffenDirk MielenzMartin HerrmannThomas HarrerArnd KleyerGerhard KrönkeLarissa Valor-Méndez

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

These data show that B cell depletion completely blocks humoral but not T cell SARS-CoV-2 vaccination response. Furthermore, limited humoral immune responses are found after SARS-CoV-2 infection in patients with B cell depletion.

Keyphrases

immune response
sars cov
respiratory syndrome coronavirus
dendritic cells
toll like receptor
multiple sclerosis
electronic health record
coronavirus disease
big data
artificial intelligence
inflammatory response
deep learning