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Dynamic genetic differentiation drives the widespread structural and functional convergent evolution of snake venom proteinaceous toxins.

Bing XieDaniel DashevskyDarin RokytaParviz GhezellouBehzad FathiniaQiong ShiMichael K RichardsonBryan Grieg Fry
Published in: BMC biology (2022)
We found novel convergences in both structural and functional evolution of snake toxins. These results provide a detailed roadmap for future work to elucidate predator-prey evolutionary arms races, ascertain differential clinical pathologies, as well as documenting rich biodiscovery resources for lead compounds in the drug design and discovery pipeline.
Keyphrases
  • genome wide
  • small molecule
  • current status
  • high throughput
  • emergency department
  • copy number
  • dna methylation
  • gene expression
  • adverse drug
  • drug induced
  • single cell