Dynamic genetic differentiation drives the widespread structural and functional convergent evolution of snake venom proteinaceous toxins.
Bing XieDaniel DashevskyDarin RokytaParviz GhezellouBehzad FathiniaQiong ShiMichael K RichardsonBryan Grieg FryPublished in: BMC biology (2022)
We found novel convergences in both structural and functional evolution of snake toxins. These results provide a detailed roadmap for future work to elucidate predator-prey evolutionary arms races, ascertain differential clinical pathologies, as well as documenting rich biodiscovery resources for lead compounds in the drug design and discovery pipeline.