MRI quantitative susceptibility mapping of the substantia nigra as an early biomarker for Lewy body disease.
Qin ChenBradley F BoeveArvin AraniMatthew L SenjemClifford R JackScott A PrzybelskiTimothy G LesnickWalter K KremersJulie A FieldsChristopher G SchwarzJeffrey L GunterJoshua D TrzaskoJonathan Graff-RadfordRodolfo SavicaDavid S KnopmanDennis W DicksonTanis J FermanNeill Graff-RadfordRonald C PetersenKejal KantarciPublished in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2021)
Our data suggested that QSM is sensitive to the increased magnetic susceptibility due to higher iron content in the substantia nigra in pDLB. The trend of increasing susceptibility from controls to iRBD and MCI-LB, and to pDLB suggests that iron deposition in the substantia nigra starts to increase as early as the prodromal stage in DLB and continues to increase as the disease progresses, independent of parkinsonism severity.