SARM1 promotes the neuroinflammation and demyelination through IGFBP2/NF-κB pathway in experimental autoimmune encephalomyelitis mice.
Jingjing ZhangLingting JinXin HuaMianxian WangJiaojiao WangXingxing XuHuitao LiuHaoyu QiuHuankun SunTianyingying DongDanlu YangXu ZhangYing WangZhi-Hui HuangPublished in: Acta physiologica (Oxford, England) (2023)
These results identified the unknown role of SARM1 in the promotion of neuroinflammation and demyelination and revealed a novel drug target pathway of SARM1/IGFBP2/NF-κB for MS.
Keyphrases
- lps induced
- inflammatory response
- signaling pathway
- lipopolysaccharide induced
- traumatic brain injury
- pi k akt
- oxidative stress
- cognitive impairment
- nuclear factor
- ms ms
- mass spectrometry
- multiple sclerosis
- cerebral ischemia
- emergency department
- type diabetes
- high fat diet induced
- adipose tissue
- skeletal muscle
- immune response