Cutaneous epithelioid hemangiomas show somatic mutations in the MAPK pathway.

K MaurusC KosnopfelH KneitzS AppenzellerDavid SchramaV GlutschS RothE Gerhard-HartmannM RosenfeldtLino MöhrmannM FröhlichD HübschmannA StenzingerH GlimmS FröhlingM GoebelerA RosenwaldH KutznerBastian Schilling

Published in: The British journal of dermatology (2021)

Taken together, our data suggest that EH shows somatic mutations in genes of the MAPK pathway which might contribute to the formation of this benign tumor.

Keyphrases

signaling pathway
oxidative stress
pi k akt
copy number
genome wide
gene expression
dna methylation
machine learning
transcription factor
cell proliferation
deep learning
bioinformatics analysis