Confocal laser endomicroscopy as predictive biomarker of clinical and endoscopic efficacy of vedolizumab in ulcerative colitis: The DETECT study.

Lucille QuénéhervéCaroline Trang-PoissonAurélie FantouMathurin FlamantTony DurandGuillaume BouguenJérémy BregeonThibauld OullierMorgane AmilMarie DewitteStéphanie BardotStéphanie BlandinCécile BraudeauMarie-Anne VibetRégis JosienMichel NeunlistArnaud Bourreille

Published in: PloS one (2024)

This pilot study demonstrate that dual-band CLE is feasible to detect α4β7- and TNF-expressing cells. Positive α4β7 staining seems to be associated with clinical and endoscopic remission in UC patients treated by anti-α4β7-integrin, subject to validation by larger-scale studies. Clinical-trial.gov: NCT02878083.

Keyphrases

ulcerative colitis
clinical trial
ultrasound guided
induced apoptosis
rheumatoid arthritis
disease activity
oxidative stress
phase ii
endoplasmic reticulum stress