Hyperpolarization of 15 N in an amino acid derivative.
Philip SaulSalvatore MamoneSergey KorchakPublished in: RSC advances (2022)
Hyperpolarization is a nuclear magnetic resonance (NMR) technique which can be used to significantly enhance the signal in NMR experiments. In recent years, the possibility to enhance the NMR signal of heteronuclei by the use of para -hydrogen induced polarization (PHIP) has gained attention, especially in the area of possible applications in magnetic resonance imaging (MRI). Herein we introduce a way to synthesize a fully deuterated, 15 N labelled amino acid derivative and the possibility to polarize the 15 N by means of hydrogenation with para -hydrogen to a polarization level of 0.18%. The longevity of the polarization with a longitudinal relaxation time of more than a minute can allow for the observation of dynamic processes and metabolic imaging in vivo . In addition, we observe the phenomenon of proton-deuterium exchange with a homogeneous catalyst leading to signal enhanced allyl moeities in the precursor.
Keyphrases
- magnetic resonance
- amino acid
- contrast enhanced
- magnetic resonance imaging
- high resolution
- solid state
- computed tomography
- diffusion weighted imaging
- high glucose
- working memory
- drug induced
- diabetic rats
- reduced graphene oxide
- highly efficient
- photodynamic therapy
- oxidative stress
- metal organic framework
- stress induced
- drosophila melanogaster