The Interaction of SWI/SNF with the Ribosome Regulates Translation and Confers Sensitivity to Translation Pathway Inhibitors in Cancers with Complex Perturbations.
Livia UlicnaSamuel C KimmeyChristopher M WeberGrace M AllardAihui WangNam Q BuiSean C BendallGerald R CrabtreeGregory R BeanCapucine Van RechemPublished in: Cancer research (2022)
This work establishes direct functions for mSWI/SNF in translation and demonstrates that alterations in mSWI/SNF confer a therapeutic vulnerability to translation pathway inhibitors in cancer cells.