Inhibition of OGG1 ameliorates pulmonary fibrosis via preventing M2 macrophage polarization and activating PINK1-mediated mitophagy.

Wenjuan WuHongxia JiaSong ChenXinran MaShuai ZhouLingxiao QiuXinhui WuPing LiHeying ChuGuojun Zhang

Published in: Molecular medicine (Cambridge, Mass.) (2024)

OGG1 inhibition protects against pulmonary fibrosis, which is partly via activating PINK1/Parkin-mediated mitophagy and retarding M2 macrophage polarization, providing a therapeutic target for pulmonary fibrosis.

Keyphrases

pulmonary fibrosis
dna repair
signaling pathway
nlrp inflammasome
mouse model
dna damage
oxidative stress