Combination vaccine based on citrullinated vimentin and enolase peptides induces potent CD4-mediated anti-tumor responses.

Victoria A BrentvilleRachael L MetheringhamIan DanielsSuha AtabaniPeter SymondsKatherine W CookMireille VankemmelbekeRuhul ChoudhuryPoonam VaghelaMohamed GijonGhislaine MeinersWillem-Jan KrebberCornelis J M MeliefLindy G Durrant

Published in: Journal for immunotherapy of cancer (2021)

Modi-1 citrullinated peptide vaccine induces potent CD4-mediated anti-tumor responses in mouse models and a CD4 T cell repertoire is present in ovarian cancer patients to the citrullinated peptides suggesting that Modi-1 could be an effective vaccine for ovarian cancer patients.

Keyphrases

mouse model
anti inflammatory
amino acid
nk cells
high throughput sequencing