Activated Coagulation FXII (Factor XII): A Unique Target for In Vivo Molecular Imaging.
Aidan P G WalshEefang YuJames D McFadyenViktoria BongcaronMitchell J MoonAngela HuangJane ArthurIneke MuirVeronika RayzmanCon PanousisXiaowei WangKarlheinz PeterPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Overall, we demonstrate that FXIIa targeting is highly suitable for the specific detection of venous and arterial thrombi. This approach will allow direct, specific, and early imaging of thrombosis in preclinical imaging modalities and may facilitate monitoring of antithrombotic treatment in vivo.