Total Synthesis of Actinorhodin.
Mamiko NinomiyaYoshio AndoFumitaka KudoKen OhmoriKeisuke SuzukiPublished in: Angewandte Chemie (International ed. in English) (2019)
The enantioselective total synthesis of actinorhodin (1) is described. The synthesis features 1) dual benzyne reactions en route to the monomer, 2) the trans-selective installation of the side chain, and 3) a regioselective oxidative dimerization.