Rare Genetic Variation and Outcome of Surgery for Mesial Temporal Lobe Epilepsy.
Piero PeruccaKate StanleyNatasha HarrisAnne M McIntoshAli Akbar Asadi-PooyaMohamad A MikatiDanielle M AndradePatricia DuganChantal DepondtHyunmi ChoiErin L HeinzenGianpiero L CavalleriRussell J BuonoOrrin DevinskyMichael R SperlingSamuel Frank BerkovicNorman DelantyDavid B GoldsteinTerence J O'Briennull nullPublished in: Annals of neurology (2022)
Rare variation contributes to the genetic architecture of MTLE, but does not appear to have a major role in failure of MTLE surgery. These findings can be incorporated into presurgical decision-making and counseling. ANN NEUROL 2022.