High Branched-Chain Amino Acid Concentrations Are Found in Preterm Baboons Receiving Intravenous Amino Acid Solutions and Mimic Alterations Found in Preterm Infants.

Cynthia L BlancoLisa McGill-VargasCun LiLauryn WinterPeter Nathanielsz

Published in: JPEN. Journal of parenteral and enteral nutrition (2019)

Early and high AA supplementation in extremely premature baboons significantly disrupted plasma AA concentrations. Elevated concentrations of branched-chain AAs and ornithine raise concerns for adverse neurodevelopmental outcomes. These results are consistent with those found in premature human infants and emphasize the need to optimize parenteral AA solutions for the unique metabolic requirements of premature infants. Improved technologies for rapid monitoring of AA concentrations during treatment are essential.

Keyphrases

amino acid
preterm infants
low birth weight
endothelial cells
type diabetes
emergency department
metabolic syndrome
preterm birth
induced pluripotent stem cells
weight loss