Osteochondritis dissecans of the knee: Epidemiology, etiology, and natural history.
Marco TuratiFilippo Maria AnghilieriMarco BigoniLuca RigamontiStephane TercierNicolas NicolaouFranck AccadbledPublished in: Journal of children's orthopaedics (2023)
Osteochondritis dissecans of the knee is a disease that typically affects skeletally immature patients. Clinically manifested with knee pain, limping, and joint disfunction, this condition has remained misunderstood and undervalued for a long period. Although being a rare condition, its awareness is of utmost clinical interest because of the possible severe consequences it can bring when misrecognized or inadequately treated. Its etiology remains unclear and is still debated. Many theories have been proposed, including inflammation, local ischemia, subchondral ossification abnormalities, genetic factors, and repetitive mechanical microtrauma, with a likely interplay of the same. This review article aims to deliver and discuss current and up-to-date concepts on epidemiology, etiology, and natural history of this pediatric condition. Level of evidence : level V.
Keyphrases
- total knee arthroplasty
- end stage renal disease
- knee osteoarthritis
- newly diagnosed
- anterior cruciate ligament
- ejection fraction
- chronic pain
- risk factors
- chronic kidney disease
- oxidative stress
- anterior cruciate ligament reconstruction
- peritoneal dialysis
- high frequency
- pain management
- early onset
- genome wide
- gene expression
- copy number
- spinal cord injury
- drug induced